Circuit response to neuromodulation characterized with simultaneous deep brain stimulation and precision neuroimaging in humans - PubMed

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Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD), but its neural mechanisms are not well understood.
The study used 3-T MRI-compatible DBS and precision imaging to collect extensive data from 14 PD patients and 27 healthy participants.
Patients underwent multiple imaging sessions under seven stimulation conditions, including functional MRI, structural MRI, and diffusion-weighted MRI.
DBS normalizes connectivity in the somatocognitive action network and evokes differential responses in the primary motor and globus pallidus circuits.
Target cortical functional connectivity predicts clinical outcomes, and the dataset is shared to accelerate research into DBS mechanisms.
The study involved multiple timepoints over a year, with each patient undergoing extensive imaging and neurological assessments.

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