Spatial multi-omics characterization of neuroblastoma reveals ferroptosis-associated metabolic features in high-risk tumors - PubMed
10 hours ago
- #neuroblastoma
- #ferroptosis
- #spatial-omics
- Spatial multi-omics (transcriptomics and proteomics) analysis of neuroblastoma identifies metabolic features linked to ferroptosis in high-risk tumors, including upregulation of fatty acid metabolism and ROS signaling.
- High-risk tumors show increased glutathione metabolism and GPX4 expression, suggesting a compensatory mechanism that may inhibit ferroptosis; GPX4 inhibition in vitro induces lipid peroxidation and reduces cell viability.
- Spatial proteomics reveals distinct niches like stroma-secluded immune cells and macrophage-rich areas in high-risk neuroblastoma, which correlate with poor patient survival and may influence ferroptosis sensitivity.
- The study proposes ferroptosis-associated pathways and macrophage-tumor interactions as potential therapeutic targets for treating high-risk neuroblastoma.