Protective Effect of Idebenone Against UVB-Induced Photoaging in HaCaT Cells - PubMed
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- #idebenone
- #photoaging
- Idebenone (IDE) mitigates UVB-induced photoaging in HaCaT cells by restoring normal cell morphology, reducing senescence markers (SA-β-gal), and improving cell migration and proliferation.
- IDE alleviates oxidative stress by lowering ROS and MDA levels while increasing SOD activity, and restores mitochondrial function through repolarization of MMP and enhanced ATP synthesis.
- It reduces secretion of pro-inflammatory factors (TNF-α, IL-1β, IL-8) and modulates gene expression, downregulating IL-3RA and restoring TUBA8, indicating multi-pathway protection against photoaging.