HMGB3: A pivotal orchestrator of therapy resistance and cancer stemness in human malignancies (Review) - PubMed
5 hours ago
- #therapy resistance
- #HMGB3
- #cancer stemness
- HMGB3 is crucial in biological processes like transcriptional regulation, chromatin remodeling, and DNA repair, with high expression during embryonic development but low in normal adult tissues.
- It is abnormally upregulated in many cancers, including leukemia and breast, bladder, colorectal, and gastric cancer, linking to poor patient prognosis.
- HMGB3 contributes to therapy resistance by maintaining cancer stemness, enhancing DNA damage repair, modulating cell death, and remodeling the tumor microenvironment, affecting chemo-, radio-, targeted, and immunotherapy.
- Targeting HMGB3 is seen as a promising strategy to overcome multidrug resistance and improve treatment outcomes in malignancies.