NSD2 inhibits the expression of PD-L1 via oxidative phosphorylation to control immune surveillance in hepatocellular carcinoma - PubMed
3 hours ago
- #NSD2
- #PD-L1
- #Hepatocellular carcinoma
- NSD2 inhibits PD-L1 expression via oxidative phosphorylation (OXPHOS) to enhance immune surveillance in hepatocellular carcinoma (HCC).
- NSD2 acts as a tumor suppressor in HCC by suppressing tumor cell proliferation in DEN-treated mice.
- Mechanistically, NSD2 inhibits OXPHOS by activating transcription of target genes (Camk2d and Prkce).
- Downregulation of OXPHOS by NSD2 overexpression reduces PD-L1 expression, improving immune recognition of tumors.
- Patients with low NSD2 expression respond better to PD-L1 inhibitor treatment.
- NSD2 alterations were characterized in HCC patients, highlighting its role in HCC development.