Auditory activity sustains adult neurogenesis and cognition through the locus coeruleus-norepinephrine system - PubMed
3 hours ago
- #hearing-loss
- #cognitive-decline
- #neurogenesis
- Hearing loss is a leading modifiable risk factor for cognitive decline and dementia.
- Mice with cochlear outer hair cell ablation show hearing loss, cognitive impairment, and defective hippocampal neurogenesis.
- The dentate gyrus receives auditory input via a neuraxis involving PnCvGluT2 and LCNEergic neurons.
- Hearing loss reduces PnCvGluT2 to LCNEergic neuronal afferents, lowering norepinephrine levels.
- Stimulating PnCvGluT2 to LCNEergic neuronal afferents rescues neurogenesis and cognitive impairment caused by hearing loss.