Age at natural menopause, reproductive lifespan and Alzheimer's disease in females: is APOE ε4 the missing link? - PubMed
3 hours ago
- #menopause
- #Alzheimer's disease
- #APOE genotype
- Later age at natural menopause and longer reproductive lifespan are associated with increased Alzheimer's disease risk in females.
- APOE ε4 allele amplifies the link between extended reproductive lifespan and higher AD risk, while ε3 attenuates it.
- The study suggests APOE genotype acts as a molecular bridge between estrogen exposure and Alzheimer's disease susceptibility.