Deconstructing senescence phenotypes in cells of the bone and bone marrow - PubMed
10 hours ago
- #Cellular Senescence
- #Bone Marrow
- #Age-Related Bone Loss
- Cellular senescence in osteogenic mesenchymal cells is a factor in age-related bone loss.
- Myeloid cells in bone marrow exhibit the strongest senescence profile among immune cells, but still less than mesenchymal stromal cells.
- Mesenchymal cells show a profound senotype, making them susceptible to senolytic clearance that protects against bone loss.
- Selective clearance of p16+ myeloid cells is not long-lasting and does not fully prevent age-related bone loss.
- The study highlights challenges in developing senolytic strategies for tissues like bone with mixed senotypes.