DGAT1 Inhibition Induces Ferroptosis and Enhances Cancer Immunotherapy Efficacy - PubMed
12 hours ago
- #cancer immunotherapy
- #DGAT1
- #ferroptosis
- DGAT1 inhibition induces ferroptosis, a form of regulated cell death driven by lipid peroxidation, in cancer cells.
- Low DGAT1 expression in human cancer cohorts correlates with improved prognosis and elevated ferroptosis-associated gene signatures.
- DGAT1 inhibition enhances immune checkpoint blockade (ICB) therapy efficacy by promoting cytotoxic T lymphocyte (CTL) infiltration.
- Mechanistically, DGAT1 inhibition reduces lipid droplet accumulation, leading to lipid peroxidation, mitochondrial dysfunction, and ROS production.
- DGAT1 inhibition results in GPX4 depletion and ferroptosis, suggesting potential for repurposing DGAT1 inhibitors in cancer immunotherapy.