Increased synovial and entheseal fibroblast activation detected by 68Ga-FAPI-PET/CT is associated with the development of psoriatic arthritis in psoriasis patients with arthralgia - PubMed
3 hours ago
- #psoriatic arthritis
- #68Ga-FAPI-PET/CT
- #fibroblast activation
- 68Ga-FAPI-PET/CT detects fibroblast activation in psoriasis patients with arthralgia, linked to higher risk of developing psoriatic arthritis (PsA).
- FAPI-positive patients (82% of the cohort) had higher BMI, more pain, and subclinical ultrasound changes compared to FAPI-negative patients.
- Pathological 68Ga-FAPI uptake was most common in large joints and mechanically stressed sites, correlating with synovial hyperplasia and entheseal Power Doppler signals.
- FAPI-positive patients showed a significantly higher risk of progression to PsA (49%) compared to FAPI-negative patients (12.5%).
- The study suggests fibroblast activation as a crucial step in the development of PsA in psoriasis patients with arthralgia.