Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture - PubMed
9 hours ago
- #liver zonation
- #single-cell analysis
- #spatial proteomics
- Single-cell Deep Visual Proteomics used to analyze protein distribution in human liver tissue.
- Study created a spatial proteome map by analyzing hundreds of hepatocytes from 18 individuals.
- About half of the 2,500 proteins identified per cell showed zonated expression patterns.
- Cross-species comparison with mice revealed conserved metabolic functions and human-specific zonation features.
- Disrupted liver architecture led to widespread loss of protein zonation, especially affecting pericentral proteins.
- Provides an open-access resource on human liver organization and a framework for spatial proteomics.