Acetylation-dependent nuclear translocation of EXOC4 regulates KU70 methylation to facilitate non-homologous end joining - PubMed
3 hours ago
- #Chemoradiotherapy resistance
- #DNA repair
- #Gastric cancer
- EXOC4 acetylation at lysine 433 by p300 induces its nuclear translocation.
- Nuclear EXOC4 promotes KU70 methylation at arginine 318 via PRMT5 interaction.
- KU70 methylation enhances DNA-binding affinity of the KU complex, improving double-strand break repair.
- Targeting EXOC4 K433 with a peptide inhibits nuclear import, reducing KU70 methylation and restoring therapy sensitivity.
- The p300-EXOC4-KU70 axis is identified as a key mediator of chemoradiotherapy resistance in gastric cancer.