Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and TKI Therapy Monitoring - PubMed
4 hours ago
- #fluorescence nanoprobe
- #PDGFRβ detection
- #TKI therapy monitoring
- PDGFRβ expression is crucial for cancer diagnosis, drug development, and therapy monitoring.
- A novel nanoprobe (Cy3-Gint4.T@BPNSs) uses fluorescence quenching-recovery to detect PDGFRβ levels.
- The nanoprobe consists of a Cy3-labeled aptamer bound to black phosphorus nanosheets, which quenches fluorescence until PDGFRβ binding releases the aptamer and restores fluorescence.
- Fluorescence intensity correlates with PDGFRβ expression, enabling tumor diagnosis and treatment guidance.
- Dynamic PDGFRβ changes induced by TKI therapy correlate with fluorescence variations, linking to potential resistance mechanisms and personalized therapy.