Stage-matched conductive hydrogel with pH/ROS/MMP9 triple-responsive salidroside release for post-infarction myocardial repair - PubMed
3 hours ago
- #myocardial repair
- #responsive drug delivery
- #smart hydrogel
- Development of PGO/CAM@Sal, a conductive hydrogel with pH/ROS/MMP9-responsive release of salidroside for post-myocardial infarction repair.
- The hydrogel matches myocardial stiffness, is injectable, self-healing, adhesive, and electrically conductive similar to native tissue.
- In vitro, it scavenges ROS, reduces inflammation, promotes M2 macrophage polarization, angiogenesis, and enhances cardiomyocyte electrical coupling.
- In a rat MI model, it bridges infarct conductivity, stabilizes electrophysiology, reduces arrhythmias, attenuates fibrosis and remodeling, improving systolic function.
- Transcriptomic analysis suggests involvement of the Mmp12/Cybb axis and related pathways in inflammation, oxidative stress, fibrosis, calcium handling, and ion transport.