Cell-autonomous and noncell-autonomous drivers of dopamine neuron vulnerability in Parkinson's disease - PubMed
3 hours ago
- #Parkinson's disease
- #dopamine neurons
- #neurodegeneration
- Parkinson's disease motor symptoms are linked to age-dependent dopamine neuron degeneration.
- Traditionally, neuron loss was attributed to cell-autonomous dysfunctions, but evidence now points to interactions between cell-autonomous and noncell-autonomous mechanisms.
- Cell-autonomous mechanisms involve mitochondrial, lysosomal, or proteasomal perturbations.
- Noncell-autonomous processes arise from glial and peripheral immune cells.
- These pathways converge to create chronic cellular stress and trigger cell death mechanisms.
- Apoptosis is a key mode of degeneration, but pyroptosis and ferroptosis also contribute.
- Understanding these mechanisms across disease stages and patient subgroups could guide neuroprotective strategies.