Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair - PubMed
8 hours ago
- #diabetic foot ulcer
- #responsive hydrogel
- #wound healing
- An intelligent-responsive hydrogel was developed to repair diabetic foot ulcers (DFU).
- The hydrogel integrates desferrioxamine-loaded Mn-doped ZIF-8 (DFO@Mn-ZIF-8) for ROS scavenging, antibacterial effects, and angiogenesis.
- It also contains umbilical cord mesenchymal stem cell-derived exosomes to aid healing.
- The hydrogel responds to glucose and ROS in the wound microenvironment for stage-specific delivery.
- In tests, it effectively cleared bacteria, remodeled the immune environment, and promoted blood vessel formation.
- This approach offers a single-platform therapy for systematic regulation of complex DFU healing factors.