"Metabolic memory" of aging: anchoring, transmission, and frontiers of transgenerational intervention - PubMed
4 hours ago
- #metabolic memory
- #aging intervention
- #cellular senescence
- Cellular senescence is central to organismal aging and age-related diseases.
- Senescent phenotypes persist even after removing stressors and may affect offspring.
- The 'aging metabolic memory' framework explains aging's persistence and heritability.
- Mitochondrial metabolic reprogramming alters the epigenetic landscape, forming stable senescence imprints.
- Senescence-associated secretory phenotype (SASP) and extracellular vesicles (EVs) transmit senescent phenotypes.
- A hypothetical model explores transgenerational transmission of aging metabolic memory via germ cells.
- Novel aging intervention strategies focus on memory intervention, including metabolic resetting and epigenetic remodeling.