Insights into the renin-angiotensin-aldosterone system in transthyretin amyloid cardiomyopathy - PubMed
4 hours ago
- #Cardiac biomarkers
- #Renin-angiotensin-aldosterone system
- #ATTR-CM
- The study characterizes RAAS patterns in ATTR-CM patients and links them to clinical, echocardiographic, and prognostic outcomes.
- Higher ACE2 activity and alternative RAAS peptides (angiotensin 1-7, angiotensin 1-5) are associated with adverse cardiac events, including HF hospitalization or cardiac death.
- Increased ACE2 activity correlates with elevated NT-proBNP levels and advanced biventricular dysfunction on echocardiography.
- ACE2 above the median predicts worse cardiac outcomes, while classical RAAS peptides do not show prognostic value.
- Findings suggest ACE2 as a potential biomarker for risk stratification in ATTR-CM patients.