Structural modeling reveals phage proteins that manipulate bacterial immune signaling - PubMed
3 days ago
- #phage proteins
- #bacterial immunity
- #nucleotide signaling
- Structural modeling identifies phage proteins that interfere with bacterial immune signaling.
- Three protein families—Sequestin, Lockin, and Acb5—inhibit bacterial immune systems like Thoeris and CBASS.
- Sequestin and Lockin act as nucleotide 'sponges,' binding immune signaling molecules like 3'cADPR and His-ADPR.
- Acb5 cleaves cyclic nucleotides such as 3'3'-cGAMP, disrupting bacterial immune responses.
- Thousands of phage homologs suggest widespread viral strategies to evade nucleotide-based immunity.