STUB1-VCP/p97 limits PINK1 overaccumulation to safeguard mitophagy and memory - PubMed
3 hours ago
- #PINK1
- #Alzheimer disease
- #mitophagy
- The STUB1-VCP/p97 axis regulates full-length PINK1 levels by targeting it for proteasomal degradation during mitophagy.
- Disruption of this regulation leads to PINK1 overaccumulation, accelerated PRKN turnover, and impaired mitophagy.
- This regulatory mechanism is compromised in Alzheimer's disease brains, causing neuronal mitophagy defects and impaired learning in C. elegans.