Integrative single-cell analysis reveals endothelial diversity in the vasa vasorum of human atherosclerosis - PubMed
3 hours ago
- #Single-cell Analysis
- #Atherosclerosis
- #Endothelial Diversity
- Single-cell transcriptomic atlas reveals endothelial diversity in human atherosclerotic plaques.
- SULF1+ arterial endothelial cells (ArtECs) undergo endothelial-to-mesenchymal transition (EndMT).
- Capillary-like endothelial cells (CapECs) drive angiogenesis via tip-stalk cell transitions and CXCL12 expression.
- Post-capillary venule endothelial cells (VenECs), especially ACKR1highNR2F2low subsets, show inflammatory signatures linked to leukocyte recruitment.
- Endothelial heterogeneity identifies SULF1+ ArtECs and VenECs as potential therapeutic targets for atherosclerosis.