Epstein-Barr virus drives nasopharyngeal carcinoma metastasis via RNA m5C modification of ICAM-1 mediated by NSUN2 and YBX3 - PubMed
3 hours ago
- #Epstein-Barr virus
- #nasopharyngeal carcinoma
- #RNA modification
- Epstein-Barr virus (EBV) infection elevates RNA m5C levels in nasopharyngeal carcinoma (NPC) cells.
- EBV upregulates NSUN2, an RNA m5C methyltransferase, via LMP1-mediated NF-κB activation.
- NSUN2 enhances NPC cell migration and metastasis through its RNA m5C catalytic activity.
- YBX3 is identified as a novel RNA m5C-binding protein ('reader') upregulated by EBV infection.
- NSUN2 catalyzes m5C modification on ICAM-1, which YBX3 recognizes, enhancing ICAM-1 translation.
- ICAM-1 overexpression rescues metastasis defects caused by NSUN2 knockdown.
- NSUN2, YBX3, and ICAM-1 expression levels correlate with NPC tumor progression and poor prognosis.
- The study suggests the LMP1/NSUN2/YBX3/ICAM-1 axis as a potential therapeutic target for NPC.