Electroacupuncture improves spatial learning and memory functions in triple-transgenic Alzheimer's disease model mice by enhancing glutamatergic synapse plasticity in the entorhinal cortex-hippocampal
3 days ago
- #Alzheimer's disease
- #Electroacupuncture
- #Synaptic plasticity
- Electroacupuncture improves spatial learning and memory in Alzheimer's disease model mice.
- Enhances glutamatergic synapse plasticity in the entorhinal cortex-hippocampal CA1 circuit.
- 4-week daily electroacupuncture at DU20/DU24 acupoints showed significant cognitive improvements.
- Chemogenetic inhibition of the circuit abrogated therapeutic effects, proving its necessity.
- Electroacupuncture reduced tau hyperphosphorylation and restored dendritic spine density.
- Boosted long-term potentiation and increased synaptic proteins.
- Activated the NMDAR-CaMKII-CREB signaling cascade.
- Multi-level neurorestorative effects: reduced tau pathology, rebuilt synaptic architecture, enhanced synaptic function.