Energy Compensation Strategy: The Frontier of Neurodegenerative Disease Treatment - PubMed
7 hours ago
- #mitochondrial therapy
- #neurodegenerative diseases
- #energy compensation
- Neurodegenerative diseases pose a significant threat to global public health.
- Mitochondrial DNA damage and protein homeostasis imbalance during aging are core pathological bases of neurodegeneration.
- Energy metabolism disorders are common pathogenic hubs in multiple neurodegenerative diseases.
- Focus on Parkinson's, Alzheimer's, and Huntington's diseases reveals pathology linked to metabolic disorders.
- Energy compensation strategies include rebuilding energy supply, systemic metabolic remodeling, supplementing alternative energy substrates, and direct energy delivery.
- Existing energy compensation strategies face technical bottlenecks, guiding future research directions.