Dysfunctional adipose tissue-lymphatic crosstalk in obesity - PubMed
3 hours ago
- #lymphatic system
- #adipose tissue
- #obesity
- The lymphatic vasculature plays roles in immunity, lipid transport, and fluid homeostasis, and is now recognized for its involvement in adipose tissue metabolism, obesity, and related comorbidities.
- Obesity is associated with impaired lymphatic function, leading to localized lymphoedema, adipogenesis, and insulin resistance.
- Compromised lymphatic vasculature integrity can induce adiposity and accelerate insulin resistance.
- Advanced 'omics' and bioinformatic technologies, along with functional experiments, reveal the lymphatic system's role in tissue and organ homeostasis, including adipose tissue.
- The review highlights the crosstalk between the lymphatic network and white and brown adipose tissues.
- Lymph-directed therapeutic strategies, such as lymph-directing glyceride prodrug technology, show potential for transforming obesity treatment outcomes.