Lipid metabolism drives dietary effects on T cell ferroptosis and immunity - PubMed
3 hours ago
- #lipid metabolism
- #T cell immunity
- #ferroptosis
- Ferroptosis is a key mechanism of non-apoptotic programmed cell death in CD4+ and CD8+ T cells.
- Dietary composition, particularly polyunsaturated and monounsaturated fatty acids (PUFAs and MUFAs), influences T cell ferroptosis resistance.
- Dietary effects on ferroptosis (DEFs) are microbiota-independent and affect T cell homeostasis and immune responses.
- Human T cell ferroptosis resistance correlates with plasma lipid profiles, showing negative associations with PUFA/MUFA ratios.
- DEFs impact T cell resilience, humoral immunity, and anti-tumor immunity, including CAR-T cell therapy.
- ACSL4, which biosynthesizes PUFA-containing phospholipids, is highly expressed in T cells and regulates follicular helper T (TFH) cell function.
- Targeting lipid metabolism could enhance vaccine efficacy and T cell-mediated immunotherapy.