CD160-competent ILC2 are crucial for the ejection of intestinal helminths by the innate immune system - PubMed
3 hours ago
- #Helminth Immunity
- #CD160
- #ILC2
- CD160+ ILC2 are a distinct subset (ST2-IL-17RB+Ki-67+) that expands during Strongyloides ratti infection.
- CD160- ILC2 are the dominant producers of type 2 cytokines and have a different phenotype (ST2+IL-17RB-Ki-67-).
- In vitro, CD160+ ILC2 lose CD160 expression and gain cytokine-producing capacity.
- CD160-deficient mice fail to expand ILC2, activate mast cells, and control helminth infection, retaining high worm burden.
- Adoptive transfer of CD160-competent ILC2 into deficient mice partially restores mast cell activation and reduces worm burden by 50%.
- CD160 expression is a critical checkpoint for developing functional ILC2 needed for anti-helminth immunity.