TGF-β signaling mediates crosstalk between CD8+ T cells and CD39+ induced Treg cells in autoimmune inflammation - PubMed
3 hours ago
- #Autoimmune inflammation
- #TGF-β signaling
- #Treg cells
- TGF-β signaling facilitates crosstalk between CD8+ T cells and CD39+ induced Treg cells in autoimmune inflammation.
- CD8+ T cells promote the differentiation of CD39+ iTregs, enhancing their immunosuppressive capacity.
- In a colitis model, CD8+ T cells reinforced iTreg-mediated suppression of Th1 and Th17 responses.
- The ROS/TGF-β signaling axis, with IRF4 in CD8+ T cells, regulates iTreg phenotype.
- CD8+ T cell-primed iTregs showed superior therapeutic efficacy in an autoimmune arthritis model.
- The study suggests harnessing CD8+ T cell-primed iTregs could improve Treg-based therapies for autoimmune diseases.