Riboflavin metabolism shapes FSP1-driven ferroptosis resistance - PubMed
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- #ferroptosis
- Riboflavin (vitamin B2) metabolism influences FSP1-driven ferroptosis resistance.
- FSP1 (ferroptosis suppressor protein 1) is a critical inhibitor of ferroptosis, aiding in the regeneration of membrane-embedded antioxidants.
- A CRISPR-Cas9 screen identified riboflavin as a key modulator of ferroptosis sensitivity, supporting FSP1 stability and antioxidant recycling.
- The riboflavin antimetabolite roseoflavin impairs FSP1 function, sensitizing cancer cells to ferroptosis.
- Targeting riboflavin metabolism presents a therapeutic strategy to modulate the FSP1-antioxidant pathway and enhance ferroptosis sensitivity.