Evaluation of Abnormal Liver Biochemical Test Results - PubMed
3 hours ago
- #liver disease
- #biochemical tests
- #hepatic fibrosis
- Liver biochemical tests (ALT, AST, alkaline phosphatase, bilirubin, prothrombin time, albumin) screen for acute and chronic liver disease.
- Elevated ALT/AST indicates hepatocellular injury; elevated alkaline phosphatase suggests cholestasis.
- Evaluation includes history, examination, imaging (steatosis, biliary dilatation), and elastography (fibrosis).
- Extrahepatic causes should be considered if liver test abnormalities are unexplained.
- Fibrosis-4 index and AST-to-platelet ratio index help estimate hepatic fibrosis.
- Liver tests assess prognosis in cirrhosis, alcohol-associated liver disease, and metabolic dysfunction-associated steatotic liver disease.
- Critically ill patients may show severe hepatocellular injury; chemotherapy patients may exhibit hepatotoxicity.
- Liver biopsy's role has diminished due to alternative diagnostic approaches.