From case to caution: hyponatremia in a patient with Duchenne muscular dystrophy on vamorolone and lessons for clinicians - PubMed

7 hours ago

Vamorolone is a dissociative glucocorticoid used in Duchenne muscular dystrophy, offering anti-inflammatory benefits with fewer side effects compared to traditional glucocorticoids.
A 13-year-old patient with DMD switched from deflazacort to vamorolone and, after six months, developed hyponatremia (119 mmol/L) during an illness, indicating potential mineralocorticoid deficiency and adrenal crisis.
Management involved intravenous hydrocortisone and fluids, emphasizing the need for stress dosing and electrolyte monitoring in patients on vamorolone, especially those on cardiac medications.

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