p38 MAPK orchestrates cross-tissue potassium homeostasis for survival - PubMed
4 days ago
- #potassium homeostasis
- #p38 MAPK
- #aging
- p38 MAPK-ATF-7 pathway regulates cross-tissue potassium homeostasis in C. elegans.
- CATP-3 P-type ATPase pump in the hypodermis is upregulated during potassium deficiency.
- This mechanism involves both cell-autonomous and ASI neuronal signals.
- The pathway is distinct from osmotic stress responses and is conserved across species.
- Findings link potassium regulation to lifespan, stress signaling, and innate immunity.
- Potential implications for aging and age-related diseases are suggested.