Ginsenoside Rb1 attenuates diabetic peripheral neuropathy pathology by functioning as a potent activator of isocitrate dehydrogenase 1 - PubMed
3 hours ago
- #Diabetic Peripheral Neuropathy
- #Isocitrate Dehydrogenase 1
- #Ginsenoside Rb1
- Ginsenoside Rb1 (Rb1) was identified as a potent activator of isocitrate dehydrogenase 1 (IDH1).
- IDH1 activity and its product, α-ketoglutarate, are suppressed in diabetic peripheral neuropathy (DPN) patients and mouse models.
- Rb1 counteracts methylglyoxal-mediated IDH1 inhibition and alleviates DPN pathology.
- Mechanisms include improving ribosomal dysfunction, enhancing mitochondrial biogenesis, and suppressing neuroinflammation.
- Pharmacological activation of IDH1 via Rb1 is a promising therapeutic strategy for DPN.