Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome - PubMed
4 days ago
- #metabolic syndrome
- #mitochondrial function
- #circadian rhythm
- Circadian clocks help organisms adapt to daily environmental changes through a transcription-translation feedback loop involving CLOCK, BMAL1, PER, and CRY.
- Disruption of circadian rhythms is linked to obesity, metabolic disease, and cancer, but the mechanism linking the clock to metabolic homeostasis is not fully understood.
- The study found that the clock regulates oxidative metabolism in adipocytes via diurnal complex I respiration.
- Disrupting the clock in mice (via genetic deletion or high-fat diet) reduces complex I respiration, impairing peroxisome proliferator-activated receptor and insulin signaling pathways.
- Restoring complex I function by expressing yeast NDI1 in adipocytes protects against diet- and circadian-induced metabolic dysfunction, independent of weight gain.
- Adipocyte circadian disruption harms metabolic health through mitochondrial complex I dysfunction, highlighting its role in metabolic regulation.