Molecular mechanisms responsible for mesenchymal stem cell-dependent improvement of islet cell transplantation - PubMed
12 hours ago
- #islet transplantation
- #mesenchymal stem cells
- #diabetes
- Islet cell transplantation is promising for type 1 diabetes but faces challenges like poor survival, immune rejection, and insufficient vascularization.
- Mesenchymal stem cells (MSCs) improve islet transplantation by secreting growth factors, immunoregulatory molecules, and pro-angiogenic factors.
- MSC-derived exosomes (MSC-Exos) deliver microRNAs and proteins, replicating MSC benefits in a cell-free manner.
- MSC-Exos enhance islet survival, functional integration, and act as immunomodulators.
- Understanding MSC and MSC-Exos mechanisms can advance co-transplantation strategies for better islet graft outcomes.