NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development - PubMed
4 hours ago
- #neocortical development
- #neurogenesis
- #transcriptomics
- NeMO Analytics is a compendium of transcriptomic data from ~200 studies on neocortical development and in vitro models.
- It applies joint matrix decomposition to mouse, macaque, and human data, identifying conserved dynamics across neurogenesis and revealing a program in primate radial glia limited to gliogenic precursors in rodents.
- Decomposition of adult human data uncovers layer-specific signatures in excitatory neurons, showing protracted maturation versus early peaking transcription factors.
- Analysis of cerebral organoids indicates that broad developmental elements are recapitulated in vitro, but many layer-specific transcriptomic programs in neuronal maturation are absent.
- NeMO Analytics is accessible to non-coding cell biologists at nemoanalytics.org for research and data contribution.