Clinical efficacy of immunotherapy in combination of locoregional therapies for advanced hepatocellular carcinoma: a systematic review and meta-analysis - PubMed
4 hours ago
- #immunotherapy
- #hepatocellular carcinoma
- #meta-analysis
- Immunotherapy combined with locoregional therapies improves outcomes in advanced hepatocellular carcinoma (HCC).
- Combination therapy showed superior overall survival (OS), progression-free survival (PFS), disease control rate (DCR), and objective response rate (ORR).
- Increased risk of grade ≥3 adverse events (AEs) and specific immune-related AEs with immunotherapy.
- Meta-analysis included 19 cohort studies with 3,720 patients.
- Locoregional therapies included TACE, HAIC, and HAIC/TACE combined with targeted agents.