Increasing incidence and changing distribution of primary cancers in therapy-related acute myeloid leukemia: A population-based study in Osaka, Japan, 1990-2020 - PubMed
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- #secondary malignancy
- #cancer epidemiology
- #therapy-related acute myeloid leukemia
- The annual incidence of therapy-related acute myeloid leukemia (tAML) in Osaka, Japan increased from 0.13 to 0.36 per 100,000 population between 1990 and 2020.
- The proportion of tAML cases among all acute myeloid leukemia (AML) cases nearly doubled over the 30-year study period.
- A more recent diagnosis period was associated with a 28% increase in tAML incidence per decade, after adjustment.
- The most common primary cancers preceding tAML were hematological malignancies (23.1%), breast cancer (14.6%), colorectal cancer (11.5%), and gastric cancer (8.7%).
- The distribution of primary cancers changed over time, with a prominent increase in breast cancer and a decrease in gastric cancer as the primary cancer.