Epigenetic silencing L3MBTL4 sensitizes esophageal cancer to DNA-PKcs inhibitor - PubMed
6 hours ago
- #Epigenetics
- #Synthetic Lethality
- #Esophageal Cancer
- L3MBTL4 expression is regulated by promoter methylation and acts as a tumor suppressor in esophageal squamous cell carcinoma (ESCC).
- L3MBTL4 inhibits cell proliferation, colony formation, induces G1/S arrest and apoptosis, and promotes ATM signaling while inhibiting NHEJ via interaction with KU70.
- Epigenetic silencing of L3MBTL4 sensitizes ESCC to DNA-PKcs inhibitor NU7441 in vitro and in vivo, suggesting synthetic lethality as a therapeutic strategy.
- Methylation of L3MBTL4 serves as a biomarker for sensitivity to DNA-PKcs inhibitors in ESCC treatment.