Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice - PubMed
7 hours ago
- #Alzheimer's disease
- #metabolic health
- #branched chain amino acids
- Dietary protein and branched-chain amino acids (BCAAs) influence metabolic health and aging.
- Restriction of isoleucine or valine, but not leucine, improved metabolic health in 3xTg AD mice.
- Distinct effects on Alzheimer's disease (AD) pathology, molecular signaling, and gene expression were observed based on the BCAA restricted.
- Short-term memory improved in male mice with any BCAA restriction, with isoleucine restriction showing the strongest effect.
- Valine restriction provided the greatest cognitive benefits for female mice.
- Targeted BCAA restriction, particularly isoleucine or valine, may offer a novel sex-specific approach to prevent or delay AD.