Age-mimicking hydrogel stiffness recapitulates the mechanical niche of the hippocampus to regulate neural stem cell senescence - PubMed
5 hours ago
- #Hydrogel
- #Neural Stem Cells
- #Aging
- Hippocampal tissue stiffness increases with age, correlating with reduced neurogenesis.
- Hyaluronic acid-laminin hydrogels were engineered to mimic age-related hippocampal stiffness.
- Age-related stiffening accelerates neural stem cell (NSC) aging, impairing proliferation and differentiation.
- Upregulation of collagen and integrin genes and downregulation of cell cycle genes were observed in aged NSCs.
- Aging alters Piezo1 expression; disrupting Piezo1 rejuvenates old NSC proliferation.
- The mechanism of NSC aging regulation by stiffness is conserved from rodents to primates.
- Potential for regenerative strategies targeting mechanotransduction pathways.