HK2-driven histone H3K18 lactylation promotes stromal cell senescence and decidualization deficiency in URSA via CUX1-mediated SASP factor transcription - PubMed
2 days ago
- #CUX1
- #URSA
- #Histone lactylation
- HK2-driven glycolysis promotes histone H3K18 lactylation (H3K18la) in URSA.
- H3K18la at the CUX1 promoter activates SASP factors, leading to stromal cell senescence.
- CUX1 depletion or glycolysis inhibition rescues senescence and decidualization deficiency.
- The HK2-H3K18la-CUX1-SASP axis links metabolic reprogramming with epigenetic regulation in URSA.
- CUX1 is identified as a potential therapeutic target for URSA.