Antiviral Treatment for Congenital Cytomegalovirus Infection in Extremely Preterm Newborn: A Case Report and Literature Review - PubMed
3 hours ago
- #Antiviral Therapy
- #Congenital CMV
- #Premature Infant
- Congenital CMV (cCMV) infection is a leading cause of non-genetic hearing loss and poses significant risks to extremely preterm infants.
- Case report describes an extremely preterm infant (26 weeks gestation) with symptomatic cCMV, treated with ganciclovir then valganciclovir, showing good clinical and neurodevelopmental outcomes.
- Literature review identified 13 extremely preterm infants treated for cCMV; common reasons for treatment were lab abnormalities (e.g., thrombocytopenia).
- Antiviral therapy with ganciclovir/valganciclovir in preterms appears feasible and safe with monitoring, but more studies on pharmacokinetics and long-term outcomes are needed.