Autophagic extracellular vesicles: a distinct secretory route linking autophagy to extracellular communication - PubMed
3 hours ago
- #Secretory Autophagy
- #Extracellular Vesicles
- #Cellular Communication
- Autophagic extracellular vesicles (AEVs) are a newly identified subtype of small extracellular vesicles below 100 nm, linking autophagy to extracellular communication.
- AEVs originate from amphisomes formed by autophagosomes fusing with multivesicular bodies, distinct from classical exosomes that depend on ESCRT-III components and RAB27A.
- AEVs contain autophagic cargos, ESCRT-III components, and RAB13, and their biogenesis involves specific ESCRT-III complex members and the GTPase RAB13.
- AEVs can be exploited by enterovirus to infect receptor-negative cells, expanding viral tropism and suggesting secretory autophagy as a key mechanism in pathogen dissemination.
- This discovery highlights extracellular vesicle heterogeneity and positions secretory autophagy as a significant contributor to intercellular communication.