Dnmt3a-dependent de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells - PubMed
7 hours ago
- #Epigenetics
- #T cell memory
- #DNA methylation
- Dnmt3a-dependent de novo DNA methylation is crucial for maintaining lineage commitment in memory Th1 and Tfh cells.
- Deletion of Dnmt3a impairs memory Th1 and Tfh cell functionality and lineage commitment, leading to aberrant Runx1 upregulation.
- Transient pharmacological DNA methyltransferase inhibition during priming enhances primary and secondary germinal center Tfh cell responses.
- Dnmt3a-mediated DNA methylation programming is essential for preserving lineage-specific functions during recall responses to infection.
- Findings suggest strategies to improve long-lived adaptive immunity against infectious diseases.