CD70/CD27 signaling promotes the pathogenesis of multiple myeloma and represents a promising therapeutic target - PubMed
4 hours ago
- #CD70/CD27 signaling
- #therapeutic target
- #multiple myeloma
- CD70/CD27 signaling plays a critical role in multiple myeloma (MM) progression.
- CD70 expression in MM cells is an independent negative prognostic factor for overall survival.
- CD70/CD27 signaling activates MAPK/ERK and Wnt pathways, promoting cell proliferation.
- High CD70 expression is observed in advanced MM stages, especially in extramedullary myeloma.
- Inhibition of CD70/CD27 signaling, via knockout or monoclonal antibodies, abrogates tumor growth in models.
- The anti-CD70 antibody cusatuzumab shows high efficacy in treating myeloma in xenotransplantation models.
- Targeting CD70 with antibodies is a promising therapeutic strategy for advanced MM.