Senescent-Like Myofibers Contribute to Anti-Regenerative Cytokine Signaling in Duchenne Muscular Dystrophy - PubMed
3 hours ago
- #Duchenne muscular dystrophy
- #muscle regeneration
- #cellular senescence
- Duchenne muscular dystrophy (DMD) is a genetic disease causing progressive muscle degeneration.
- p16 expression in skeletal muscles induces cellular senescence in DMD rats, while its ablation enhances muscle regeneration.
- RNA-seq analysis showed p16-dependent upregulation of cytokine genes in DMD rat muscles, altering systemic blood cytokine profiles.
- Transplanted muscle regeneration was suppressed in DMD rats but improved with p16 ablation.
- p16 was found in myofibers of DMD rats, which exhibited p16-dependent cytokine expression.
- Cytokines from senescent-like myofibers create an anti-regenerative niche in DMD, revealing new disease progression mechanisms and therapeutic targets.