A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy - PubMed
5 days ago
- #photothermal therapy
- #calcium influx
- #osteoarthritis
- A photothermal nanotransducer (M2M@BPSC) was developed for osteoarthritis (OA) therapy.
- M2M@BPSC induces mild hyperthermia in macrophages under NIR stimulation, inhibiting TRPV4 channels to prevent calcium overload.
- TRPV4 suppression promotes STAT6 nuclear translocation, enhancing M2 macrophage polarization.
- M2-polarized macrophages restore balance between cartilage ECM degradation and fibrosis ECM production.
- The study identifies a thermosensitive ion channel-targeting strategy for OA microenvironment modulation.