The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling - PubMed
4 hours ago
- #ACSL family
- #ferroptosis
- #cancer metabolism
- The ACSL family plays multifaceted roles in cancer, including metabolic reprogramming, ferroptosis regulation, and tumor immune microenvironment remodeling.
- ACSL isoforms (ACSL1-ACSL6) have distinct and context-dependent effects in cancer, influencing tumorigenesis, progression, and therapy response.
- ACSL1 promotes an immunosuppressive tumor immune microenvironment (TIME) via M2 macrophage polarization.
- ACSL3 and ACSL4 have antagonistic roles in ferroptosis regulation.
- ACSL5 exhibits dual effects through lipid metabolism, apoptosis, and immunity.
- ACSL6 is involved in autophagy and hematological malignancies.
- Dysregulation of ACSL isoforms correlates with tumor progression, drug resistance, and immunotherapy response.
- Emerging ACSL-targeted therapies show significant translational potential in cancer treatment.
- Future research should focus on optimizing isoform-selective inhibitors and exploring synergistic effects with existing therapies like immune checkpoint inhibitors and radiotherapy.