Associations Between Obesity, Diabetes Mellitus, and Pancreatic Cancer in the Japanese Population: A Mendelian Randomization Study - PubMed
2 days ago
- #Pancreatic Cancer
- #Mendelian Randomization
- #Type 2 Diabetes
- The study investigates the associations between BMI, type 2 diabetes (T2D), and pancreatic cancer risk in the Japanese population using Mendelian Randomization (MR).
- Genetic predisposition to T2D, assessed using 891 SNPs, was associated with an increased risk of pancreatic cancer (OR: 1.16; 95% CI: 1.08-1.25 per 1-unit increase in ln odds of T2D).
- Genetically indexed BMI showed no association with pancreatic cancer risk (OR: 1.00; 95% CI: 0.95-1.04 per 1 kg/m² increase).
- The association between T2D and pancreatic cancer remained significant after adjusting for BMI (OR: 1.15; 95% CI: 1.07-1.24), while BMI was not significant in any analysis.
- The study supports a modest causal association of T2D, independent of BMI, with pancreatic cancer risk.